1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer's disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index.