Preface. Part I An Historical overview of the war on cancer. The four-decade journey to the National Cancer Act of 1971. Part II Cancer through the ages -- An historical overview: From prehistory to WW11 -- Our current knowledge -- Environmental carcinogens -- Part III Cancer statistics -- Assessing the enormity of the problem -- An uncontrolled problem -- Part IV How is advanced cancer treated?-The cancer-cell kill paradigm and beyond.- Complementary and alternative medicine -- The cell-kill paradigm: Bleak outcomes. Part V Stakeholders' role in the status quo -- The role of the National Cancer Institute -- Factors that impact Oncology research and practice -- The complex physician-patient interaction: Expectations vs. reality. Part VI A paradigm shift in cancer management.- Prevention & Early detection -- The holistic management of advanced cancer: A three-stage blueprint. Conclusions. References. Index.