Preface -- Epigenetics and Nutrition -- Calorie restriction as a potent epigenetic modifier -- Anti-inflammatory action of calorie restriction for aging intervention -- Hormonal influence and modulation on aging -- Epigenetic modification by exercise -- Physiological bases and underlying mechanisms of exercise -- Sarcopenia and its intervention -- Nutritional impacts on osteopenia and osteoporosis -- Nutritional interventions for cardiac aging and age-related cardiovascular diseases -- Nutritional influence on aging brain -- Mechanistic bases of calorie restriction mimetics -- Lessons learned from calorie restricted non-human primate research.