Preface -- History -- Chap. 1 Why and How Epstein-Barr Virus was discovered 50 years ago - Anthony Epstein, University of Oxford, UK -- Chap. 2. Tumor associations of EBV - historical perspectives - George Klein, Karolinska Institutet, Stockholm, Sweden -- Chap. 3. EBV-specific immune response: early research and personal reminiscences - Denis J. Moss and Viviana P. Lutzky, Queensland Institute of Medical Research, Brisbane, Australia -- Virus genetics and epigenetics -- Chap. 4. Epstein Barr virus strain variation - Paul J. Farrell, Imperial College, London, UK -- Chap. 5. Chromatin Structure of Epstein-Barr Virus Latent Episomes  - Paul M. Lieberman, University of Pennsylvania, Philadelphia, USA -- Chap. 6. The epigenetic life cycle of Epstein-Barr virus - Wolfgang Hammerschmidt, Helmholtz Center Munich, Germany. Chap. 7. Epstein-Barr virus: from the detection of sequence polymorphisms to the recognition of viral types - Regina Feederle, Olaf Klinke, Anton Kutikhin, Remy Poirey, Ming-Han Tsai and Henri-Jacques Delecluse, German Cancer Research Center, Heidelberg, Germany -- Viral infection and associated diseases -- Chap. 8. EBV persistence - introducing the virus - David A. Thorley-Lawson, Tufts University, Boston, USA -- Chap. 9. Infectious mononucleosis - Samantha K. Dunmire, Kristin A. Hogquist and Henry H. Balfour, Jr., University of Minnesota, Minneapolis, USA -- Chap. 10. Primary immunodeficiencies associated with EBV disease - Jeffrey I. Cohen, National Institutes of Health, Bethesda, USA -- Chap. 11. Burkitt's lymphoma - Rosemary Rochford  and Ann M. Moormann, University of Massachusetts, Worcester, and Upstate University of New York, Syracuse, USA -- Chap. 12. Contribution of the Epstein-Barr virus to the pathogenesis of Hodgkin lymphoma - Paul Murray and Andrew Bell, University of Birmingham, UK -- Chap. 13. The role ofEBV in the pathogenesis of diffuse large B cell lymphoma - Jane A. Healy and Sandeep S. Dave, Duke University, Raleigh, USA -- Chap. 14. Nasopharyngeal carcinoma:  an evolving role for the Epstein Barr virus - Nancy Raab-Traub, University of North Carolina, Chapel Hill, USA.-Chap. 15. EBV and autoimmunity - Alberto Ascherio and Kassandra Munger, Harvard University, Boston, USA -- Index.