History of Leptospirosis and Leptospira -- Systematics of Leptospiraceae -- Leptospiral Structure, Physiology and Metabolism -- Genomics, Proteomics and Genetics of Leptospira -- Leptospirosis in Humans -- Animal Leptospirosis -- The Molecular Basis of Leptospiral Pathogenesis -- The Leptospiral Outer Membrane -- Host Response to Leptospira Infection -- Vaccines Against Leptospirosis -- The Role of Leptospirosis Reference Laboratories.