Part 1. Mechanisms -- Thromboinflammation in Therapeutic Medicine -- Complement Interactions with Blood Cells, Endothelial Cells and Microvesicles in Thrombotic and Inflammatory Conditions -- Role of Complement on Broken Surfaces after Trauma -- Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches -- Part 2. Biomaterials -- The Lectin Pathway of Complement and Biocompatibility -- Foreign Body Reaction to Subcutaneous Implants -- Molecular Characterization of Macrophage-Biomaterial Interactions -- Heparan Sulfate Proteoglycan Metabolism and the Fate of Grafted Tissues -- Part 3. Transplantation -- Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127 -- Macro encapsulated Pig Islets Correct Induced Diabetes in Primates up to 6 Months -- Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation-Points for Therapeutic Interventions -- Cell Surface Engineering for Regulation of Immune Reactions in Cell Therapy -- Complement Interception Across Humoral Incompatibility in Solid Organ Transplantation-A Clinical Perspective.