1. Introduction to Molecular Similarity and Chemical Space -- 2. The Chemical Space of Flavors.- 3. Chemoinformatics Analysis and Structural Similarity Studies of Food-Related Databases -- 4. Reverse Pharmacognosy: A Tool to Accelerate the Discovery of New Bioactive Food Ingredients -- 5.  Molecular Approaches to Explore Natural and Food-Compound Modulators in Cancer Epigenetics and Metabolism -- 6.  Discovery of natural products that modulate the activity of PPARgamma: a source for new antidiabetics -- 7.  DPP-IV, An Important Target for Anti-diabetic Functional Food Design.-8.  Comparison of Different Data Analysis Tools to Study the Effect of Storage Conditions on Wine Sensory Attributes and Trace Metal Composition.- 9.  Software and Online Resources: Perspectives and Potential Applications.