Chapter List of Contributors -- chapter Preface -- chapter 1 Thrombosis and therapeutic antidotes: historical aspects -- Louis R Caplan Thrombosis takes center stage -- chapter 2 Antithrombotic drugs: anticoagulants (heparins) -- Ańgel Chamorro Unfractionated heparin (UFH) / chapter 3 Fibrinolytic agents -- Roger Lijnen, Nobuo Nagai, and Deśire ́Collen / chapter 4 The vessel wall in thrombosis: relevance to acute stroke therapy / chapter 5 Thrombosis, atherothrombosis, and thromboembolism in the etiology of stroke / chapter 6 Thrombolytic/antithrombotic clinical trials in cardiology: an overview -- Daniel Jenni and Jur̈g-Hans Beer / chapter 7 Study design for thrombolytic and antithrombotic treatment trials in acute stroke: mistakes and lessons / chapter 8 Unfractionated heparin, low-molecular-weight-heparins, and heparinoids in acute stroke / chapter 9 Aspirin in acute stroke / chapter 10 Platelet glycoprotein IIb/IIIa antagonists / chapter 11 New antithrombotics and their potential use -- Patrik Michel Thrombosis and antithrombotics in acute stroke: current knowledge / chapter 12 Fibrin-degrading drugs in acute stroke / chapter 13 Thrombolytic therapy for acute stroke: the studies -- Peter D Schellinger, Jochen B Fiebach, and Peter A Ringleb -- chapter 14 Complications of thrombolysis / chapter 15 Implementation of thrombolytic therapy for stroke in routine practice -- Guntram W Ickenstein, Heinrich J Audebert, and Nils Gunnar Wahlgren / chapter 16 Imaging of the ischemic penumbra / chapter 17 Thrombolytic therapy for ischemic stroke: to select or not to select / chapter 18 Intra-arterial thrombolysis for acute ischemic stroke -- Anthony J Furlan and Herman Zeumer Intra-arterial thrombolysis / chapter 19 Various combined approaches: present and future -- Danilo Toni, Svetlana Lorenzano, Romesh Markus, and Geoffrey Donnan intra-arterial thrombolysis / chapter 20 Cerebral venous thrombosis