ch. 1. The idiosyncratic problems associated with pain research / Lawrence Kruger -- ch. 2. Assessing nociception in murine subjects / Jeffrey S. Mogil, Sonya G. Wilson, and You Wan -- ch. 3. Techniques for mutagenesis of the murine opioid system in vivo / Michael D. Hayward and Malcolm J. Low -- ch. 4. Animal models of pain / Gary J. Bennett -- ch. 5. Methods in visceral pain research / Timothy J. Ness and Gerald F. Gebhart -- ch. 6. The cytokine challenge : methods for the detection of central cytokines in rodent models of persistent pain / Sarah M. Sweitzer, Janice L. Arruda, and Joyce A. DeLeo -- ch. 7. Extracellular sampling techniques / Igor Spigelman. [et al.] -- ch. 8 Electrophysiological recording techniques in pain research / Igor Spigelman, Michael S. Gold, and Alan R. Light -- ch. 9. Membrane properties : ion channels / Michael S. Gold -- ch. 10. Anatomical methods in pain research / Susan M. Carlton and Andrew Todd -- ch. 11. Quantitative morphology in relation to long-term pain states : estimates of neuron numbers / Richard E. Coggeshall -- ch. 12. Functional brain imaging in humans : methodology and issues / Karen D. Davis -- ch. 13. Methods for imaging human brain pathophysiology of chronic pain / A. Vania Apkarian. [et al.] -- ch. 14. Methods for induction and assessment of pain in humans with clinical and pharmacological examples / Thomas Graven-Nielsen. [et al.].