1. Introduction to toxicologic biomarkers / Anthony P. DeCaprio -- 2. Challenges in the statistical analysis of biomarker data / Stephen W. Looney and Joseph L. Hagan -- 3. Biomarkers of toxicant exposure / Ken Sexton -- 4. Biomarkers in environmental epidemiology / Christopher P. Wild -- 5. Use of biomarkers in health risk assessment / Annette Santamaria, Laura Ferriby, Mark Harris, and Dennis Paustenbach -- 6. Biomarkers of toxicant susceptibility / Sofia Pavanello -- 7. Identification and use of biomarkers in preclinical toxicologic safety assessment / Donna M. Dambach and Jean-Charles Gautier -- 8. Use of biomarkers in clinical toxicology and clinical trials : a critical assessment of QTc interval Profilongation as a biomarker / Daniel Bloomfield and John A. Wagner -- 9. Regulatory guidance and validation of toxicologic biomarkers / Federico M. Goodsaid and Felix W. Frueh -- 10. Use of biomarkers in occupational safety and health / Edward V. Sargent -- 11. Toxicogenomic and toxicoproteomic approaches for biomarkers / Joshua W. Hamilton -- 12. Biomarkers of chemical warfare agents / William J. Smith and Harry Salem -- 13. Applications of biomarkers in toxic tort and forensic litigation / Gary E. Marchant.