1. Genetic susceptibility to colorectal cancer / Rebecca A. Barnetson and Malcolm G. Dunlop -- 2. Epidemiology of colorectal cancer / Julian Little and Linda Sharp -- 3. Colorectal cancer screening / Robert J. C. Steele -- 4. Pathology / Christian Wittekind -- 5. Familial cancer management / Sabine Tejpar -- 6. The surgical principles of managing colorectal cancer / Ian R. Daniels and Richard J. Heald -- 7. Adjuvant therapy for colorectal cancer / Geoff Chong and David Cunningham -- 8. The role of radiotherapy in the treatment of rectal cancer / Rob Glynne-Jones and Rob Hughes -- 9. The treatment of metastatic colorectal cancer / Eric Van Cutsem and Leonard Saltz -- 10. Hepatic directed therapy / Gregory D. Leonard and Nancy E. Kemeny -- 11. Pharmacogenomics of colorectal cancer / Patrick Johnston, Wendy L. Allen, and Howard L. McLeod -- 12. Drug development for advanced colorectal cancer in the United States / Igor Puzanov and Mace L. Rothenberg.