Providing evidence of therapeutic benefit in clinical drug development / Steven Kesten and Theodore J. Witek -- Use of expiratory airflows and lung volumes to assess outcomes in COPD / Gary T. Ferguson -- Exercise testing / Denis E. O'Donnell and Katherine A. Webb -- Sleep-related breathing disturbances in COPD / Walter T. McNicholas -- Airway and alveolar determinants of airflow limitation in COPD / Noe Zamel -- Gas exchange / Antoni Ferrer, Joan Albert Barbera, and Roberto Rodriguez-Roisin -- Genetics of COPD / Jian-Quing He, Ikuma Kasuga, and Peter D. Pare -- Dyspnea / Donald A. Mahler -- Exacerbations of COPD / Jadwiga A. Wedzicha -- Health status measurement in COPD / Paul W. Jones -- Health resource utilization / Mitchell Friedman -- Anticholinergics / Peter J. Barnes -- [Alpha]-adrenergic receptor agonist bronchodilators in the treatment of COPD / Stephen I. Rennard -- Theophylline and phosphodiesterase inhibitors in COPD / Alicia R. ZuWallack and Richard L. ZuWallack -- Corticosteroids in COPD / Mario Cazzola, Maria Gabriella Matera, and Romain Pauwels -- Antioxidants and protease inhibitors / Mario Cazzola and Maria Gabriella Matera -- An integrated approach to the pharmacological therapy of COPD / Bartolome R. Celli.