chapter 1 Epidemiology of recurrent pregnancy loss / chapter 2 Signaling between embryo and mother in early pregnancy: Basis for development of tolerance / chapter 3 Genetics of spontaneous abortions / chapter 4 Does the maternal immune system regulate the embryo's response to teratogens? / chapter 5 Fetal structural malformations embryoscopy / chapter 6 Endocrinology of pregnancy loss / chapter 7 Antiphospholipid syndrome pathophysiology / chapter 8 Diagnosis of aPL-associated abortions Marighoula Varla-Leftherioti -- chapter 9 Management of antiphospholipid syndrome in pregnancy Wendell A Wilson and Nigel Harris -- chapter 10 Defects in coagulation factors leading to recurrent pregnancy loss / chapter 11 Uterine anomalies and recurrent pregnancy loss / chapter 12 Immunobiology of recurrent miscarriage -- chapter 13 Infections and recurrent pregnancy loss / chapter 14 Midtrimester loss the role of cerclage / chapter 15 Midtrimester loss and viability / chapter 16 Obstetric outcomes after recurrent pregnancy loss / chapter 17 Coping with recurrent pregnancy loss: Psychological mechanisms / chapter 18 Methodological issues in evidence-based evaluation of treatment for recurrent miscarriage / chapter 19 Investigation protocol for recurrent pregnancy loss / chapter 20 A patient's perspective