chapter 1 Epidemiology, Symptomatology, and Diagnosis / chapter 2 Substrates of Sadness: The Pathophysiology of Depression / chapter 3 Drug Development, Psychotherapy Development, and Clinical Use / chapter 4 Treatment Outcomes with Acute Pharmacotherapy/ Psychotherapy / chapter 5 Depression: Treatment Outcomes with Long-Term Maintenance -- chapter 6 Combining Medications to Achieve Remission / chapter 7 Combining Drug Treatments to Achieve Better Tolerability and Adherence / chapter 8 Depression and Genetics / chapter 9 Depression, Neuroimaging and Neurophysiology / chapter 10 Depression and Somatic Treatments / chapter 11 Medication and Psychotherapy Options and Strategies: The Future