chapter 1 Ligandin and Glutathione S-Transferases: Historical Milestones -- chapter 2 Families of Glutathione Transferases -- chapter 3 Mammalian Glutathione S-Transferase Genes: Structure and Regulation -- chapter 4 Combinatorial Protein Chemistry in Three Dimensions: A Paradigm for the Evolution of Glutathione Transferases with Novel Activities -- chapter 5 Substrates and Reaction Mechanisms of Glutathione Transferases -- chapter 6 Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides -- chapter 7 GST Polymorphism: Where to Now? Clinical Applications and Functional Analysis -- chapter 8 Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development -- chapter 9 Physiological Substrates of Glutathione S-Transferases -- chapter 10 Glutathione S-Transferases as Modulators of Signal Transduction -- chapter 11 Glutathione-Conjugate Transport and Stress-Response Signaling: Role of RLIP76 -- chapter 12 Glutathione S-Transferases and Oxidative Injury of Cardiovascular Tissues -- chapter 13 Mitochondrial Glutathione S-Transferase Pool in Health and Disease -- chapter 14 Activation of Microsomal Glutathione Transferase1 in Toxicology -- chapter 15 Glutathione S-Transferase Isozyme Composition of HumanTissues -- chapter 16 Enzymology of Glutathione S-Transferases: Laboratory Methods.