chapter 1 Structural Biology and Structural Genomics: A Federal Agency Perspective / chapter 2 Producing Proteins -- chapter 3 Crystallization of Membrane Proteins -- chapter 4 Prospects for High-Throughput Structure Determination by X-Ray Crystallography -- chapter 5 Prospects for High-Throughput Structure Determination of Proteins by NMR Spectroscopy -- chapter 6 Automated Molecular Replacement -- chapter 7 Comparative Protein Structure Modeling -- chapter 8 Rising Accuracy of Protein Secondary Structure Prediction -- chapter 9 Novel Fold and Ab Initio Methods for Protein Structure Generation -- chapter 10 Identifying Errors in Three-Dimensional Protein Models -- chapter 11 Comparative Analysis and Evolutionary Classification of Protein Structures -- chapter 12 Automated Genome Functional Annotation for Structural Genomics -- chapter 13 The Importance of Structure-Based Function Annotation to Drug Discovery -- chapter 14 The Protein Data Bank -- chapter 15 The European Bioinformatics Institute Macromolecular Structure Database (E-MSD) -- chapter 16 Molecular Docking in Structure-Based Design -- chapter 17 Use of Pharmacophores in Structure-Based Drug Design -- chapter 18 The Structure of Human lnterferon-�-1a (Avonex�) and its Relation to Activity: A Case Study of the Use of Structural Data in the Arena of Protein Pharmaceuticals -- chapter 19 G-Protein-Coupled Receptors: Diverse Functions and Shared Mechanisms of Action Interpreted Through the Structure of Rhodopsin -- chapter 20 Functional Assessment of Amino Acid Variation Caused by SingleNucleotide Polymorphisms: A Structural View.