Protein folding and misfolding, relevance to disease and function / Massimi Stefani -- Alzheimer's disease / Charlotte E. Teunissen and Tischa M. van der Cammen -- Improving Cholinergic Transmission -- Cholinergic transmission and acetylcholine release enhancers / Pierre Francotte, Pascal de Tullio and Bernard Pirotte -- AChE and its inhibition / Jure Stojan -- AChE inhibitors and their clinical assessment / Pierre Francotte, Pascal de Tullio and Bernard Pirotte -- Reduction in plaque formation / Christian Czech, Helmut Jacobsen and Celine Adessi -- Non-steroidal anti-inflammatory drugs (NSAIDs) / Bruno P. Imbimbo and Francesca Speroni -- 3-hydroxy-3-methyl-glutaryl-coenzyme reductase inhibitors / Dario Cattaneo -- A' polymerization reduction / Harry LeVine III and Corrine E. Augelli-Szafran -- Carbonic anhydrase activators as potential anti-Alzheimer's disease agents / Claudiu T. Supuran and Andrea Scozzafava -- Detection and reduction of neurofibrillary lesions / Jeff Kuret -- Protein misfolding in Alzheimer disease : pathogenic or protective? / Rudy J. Castellani. [et al.] -- Enhancement of brain retinoic acid levels / Ann B. Goodman. [et al.] -- Parkinson's disease : what is it? what causes it? and how can it be cured? / Tom Foltynie, Andrew W. Michell and Roger A. Barker -- Restoring dopamine levels / Nuno Palma. [et al.] -- Huntington's disease / Claire-Anne Gutekunst and Fran Norflus -- Amyotrophic lateral sclerosis (motor neuron disease) / Teresa Sanelli. [et al.] -- Transmissible spongiform encephalopathies (TSEs) / Michael D. Geschwind and Giuseppe Legname -- Overview / H. John Smith, Claire Simons and Robert D.E. Sewell.