Overview of wound healing in different tissue types / John D. Stroncek and William M. Reichert -- Considerations for chronically implanted electrodes for brain interfacing / Warren M. Grill -- Thermal considerations for the design of an implanted cortical brain-machine-interface / Patrick D. Wolf -- In vitro models for neuroelectrodes: a paradigm for studying tissue-materials interactions in the brain / Vadim Polikov. [et al.] -- In vivo solute diffusivity in brain tissue surrounding indwelling neural implants -- Michael J. Bridge and Patrick A. Tresco -- A molecular perspective on understanding and modulating the performance of chronic CNS recording electrodes / Wei He and Ravi V. Bellamkonda -- Soft, fuzzy, and bioactive conducting polymers for improving the chronic performance of neural prosthetic devices / Dong-Hwan Kim. [et al.] -- Strategies for regeneration and repair in the injured CNS / Molly S. Shoichet. [et al.].