chapter Section I: Cellular Metabolism -- chapter 1 Solute Transport Processes in the Cell -- chapter 2 Catabolism and Metabolic Fueling Processes -- chapter 3 Biosynthesis of Cellular Building Blocks: The Prerequisites of Life -- chapter 4 Polymerization of Buliding Blocks to Macromolecules Polyhydroxyalkanoates as an Example -- chapter 5 Rare Metabolic Conversions-Harvesting Diversity through Nature -- chapter Section II: Balances and Reaction Models -- chapter 6 Growth Nutrients and Diversity -- chapter 7 Mass Balances, Rates, and Experiments -- chapter 8 Data Reconciliation and Error Detection -- chapter 9 Black Box Models for Growth and Product Formation -- chapter 10 Metabolic Models for Growth and Product Formation -- chapter 11 A Thermodynamic Description of Microbial Growth and Product Formation -- chapter Section III: Bacterial Transcriptional Regulation of Metabolism -- chapter 12 Transcribing Metabolism Genes: Lessons from a Feral Promoter -- chapter 13 Regulation of Secondary Metabolism in Bacteria -- chapter 14 A Synthetic Approach to Transcriptional Regulatory Engineering -- chapter Chpater IV. Modeling Tools for Metabolic Engineering -- chapter 15 Metabolic Flux Analysis -- chapter 16 Metabolic Control Analysis -- chapter 17 Structure and Flux Analysis of Metabolic Networks -- chapter 18 Constraint-Based Genome-Scale Models of Cellular Metabolism -- chapter 19 Multiscale Modeling of Metabolic Regulation -- chapter 20 Validation of Metabolic Models -- chapter Section V: Developing Appropriate Hosts for Metabolic Engineering -- chapter 21 Escherichia coli as a Well-Developed Host for Meabolic Engineering -- chapter 22 Metabolic Engineering in Yeast -- chapter 23 Metabolic Engineering of Bacillus subtilis -- chapter 24 Metabolic Engineering of Streptomyces -- chapter 25 Metabolic Engineering of Filamentous Fungi -- chapter 26 Metabolic Engineering of Mammalian Cells.