chapter 1 Biochemical Characterization of Amyloid Precursor Protein -- chapter 2 Assays for Analysis of APP Secretion and Recycling -- chapter 3 Strategies for Crystallizing the N-Terminal Growth Factor Domain of Amyloid Precursor Protein -- chapter 4 Analysis of Amyloid Precursor Protein Processing Protease -Secretase: Tools for Memapsin 2 ( -Secretase) Inhibition Studies -- chapter 5 Assays for Amyloid Precursor Protein -Secretase Activity -- chapter 6 Cell-Free Reconstitution of -Amyloid Production and Trafficking -- chapter 7 Studying Amyloid -Protein Assembly -- chapter 8 Intracecellular Accumulation of Amyloid and Mitochondrial Dysfunction in Down's Syndrome -- chapter 9 Linking Alzheimer's Disease, -Amyloid, and Lipids: A Technical Approach -- chapter 10 Regulation of Amyloid Precursor Protein Processing by Lithium -- chapter 11 Immunocytochemical Analysis of Amyloid Precursor Protein and Its Derivatives -- chapter 12 Pathological Detection of A and APP in Brain -- chapter Chaptre 13. Creating APP Transgenic Lines in Mice -- chapter 14 Generation of Amyloid Precursor Protein Knockout Mice.