ch. 1. Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin -- ch. 2. Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda -- ch. 3. Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes -- ch. 4. Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland -- ch. 5. High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell -- ch. 6. Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri -- ch. 7. Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray -- ch. 8. Pharmaceutical development for HD / Richard J. Morse. [et al.] -- ch. 9. RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin -- ch. 10. Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan. [et al.] -- ch. 11. Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas -- ch. 12. Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson.