ch. 1. Animal models of depression / Damian Refojo and Jan M. Deussing -- ch. 2. Neurophysiological and neuropsychological models of depression / Stephan Moratti, Albert Fernandez, and Gabriel Rubio -- ch. 3. Neural foundations of major depression : classical approaches and new frontiers / J. Paul Hamilton, Daniella J. Furman, and Ian H. Gotlib -- ch. 4. Genetic regulation of emotion brain circuitries / Ulrich Rabl. [et al.] -- ch. 5. Development of brain monoaminergic systems / Marten P. Smidt -- ch. 6. Contribution of pharmacology to development of monoaminergic hypotheses of depression / Francisco Lopez-Munoz and Cecilio Alamo -- ch. 7. Serotonergic pathways in depression / Stefanie C. Altieri. [et al.] -- ch. 8. Noradrenergic system in depression / J. Javier Meana, Luis F. Callado, and Jesus A. Garcia-Sevilla -- ch. 9. Glutamatergic system and mood disorders / Rodrigo Machado-Vieira and Carlos A. Zarate Jr. -- ch. 10. Role of the endocannabinoid system in etiopathology of major depression / Ryan J. McLaughlin, Francis Rodriguez Bambico, and Gabriella Gobbi -- ch. 11. Opioid system and depression / Cristina Alba-Delgado. [et al.] -- ch. 12. Chronobiological rhythms, melatonergic system, and depression / Cecilio Alamo and Francisco Lopez-Munoz -- ch. 13. Corticotropin-releasing factor and hypothalamic-pituitary-adrenal axis regulation of behavioral stress response and depression / Glenn R. Valdez -- ch. 14. Depression and cytokine-regulated pathways / Bernhard T. Baune -- ch. 15. Tachykinins and tachykinin receptor antagonists in depression : therapeutic implications / Tih-Shih Lee and K. Ranga Krishnan -- ch. 16. Role of neuropeptide Y in depression : current status / Julio Cesar Morales-Medina and Remi Quirion -- ch. 17. Nitric oxide signaling in depression and antidepressant action / Gregers Wegener and Aleksander A. Mathe -- ch. 18. Beta-arrestins in depression : a molecular switch from signal desensitization to alternative intracellular adaptor functions / Sofia Avissar and Gabriel Schreiber -- ch. 19. Brain-deprived neurotrophic factor and major depression / Kazuko Sakata -- ch. 20. Role of cyclic nucleotide phosphodiesterases in depression and antidepressant activity / Ying Xu, Han-Ting Zhang, and James M. O'Donnell -- ch. 21. Vascular depression : a neuropsychological perspective / Benjamin T. Mast. [et al.] -- ch. 22. Neurobiological basis for development of new antidepressant agents / Cecilio Alamo and Francisco Lopez-Munoz.