chapter 1 Introduction -- chapter 2 Camptothecin and Its Analogs -- chapter 3 The Discovery and Development of the Combretastatins -- chapter 4 Homoharringtonine and Related Compounds -- chapter 5 Podophyllotoxins and Analogs -- chapter 6 Taxol and Its Analogs -- chapter 7 The Vinca Alkaloids -- chapter 8 The Bryostatins -- chapter 9 The Isolation, Characterization, and Development of a Novel Class of Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins -- chapter 10 Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons -- chapter 11 The Dolastatins: Novel Antitumor Agents from Dolabella auricularia -- chapter 12 Ecteinascidin 743 (ET-743; Yondelis™), Aplidin, and Kahalalide F -- chapter 13 Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B -- chapter 14 HTI-286, A Synthetic Analog of the Antimitotic Natural Product Hemiasterlin -- chapter 15 The Actinomycins -- chapter 16 Anthracyclines -- chapter 17 Ansamitocins (Maytansinoids) -- chapter 18 Benzoquinone Ansamycins -- chapter 19 Bleomycin Group Antitumor Agents -- chapter 20 Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides -- chapter 21 Epothilone, a Myxobacterial Metabolite with Promising Antitumor Activity -- chapter 22 Enediynes -- chapter 23 The Mitomycins -- chapter 24 Staurosporines and Structurally Related Indolocarbazoles as Antitumor Agents -- chapter 25 Combinatorial Biosynthesis of Anticancer Natural Products -- chapter 26 Developments and Future Trends in Anticancer Natural Products Drug Discovery*.