part SECTION I Basic Bone Biology and Tissue Engineering -- chapter 1 Developmental Biology of the Skeletal System -- chapter 2 Bone Physiology Dynamics -- chapter 3 Cell Biology of the Skeletal System: Osteoblasts, Osteocytes, Osteoclasts, Bone Marrow Stromal Cells -- part SECTION II Basic Bone Biology and Scaffold Designs for Tissue -- chapter 4 The Organic and Inorganic Matrices -- chapter 5 Signaling Molecules for Tissue Engineering -- chapter 6 Biodegradable Polymers and Microspheres in Tissue Engineering -- chapter 7 Design and Fabrication of Bone Tissue Engineering Scaffolds -- part SECTION III Applied Principles of Bone Tissue Engineering -- chapter 8 Study Design and Statistical Analysis -- chapter 9 Animal Models for Bone Tissue Engineering of Critical-sized Defects (CSDs), Bone Pathologies and Orthopedic Disease States -- chapter 10 Biomechanics -- part SECTION IV Clinical Opportunities -- chapter 11 Tissue Engineering of Bone -- chapter 12 Clinical Challenges and Contemporary Solutions: Craniofacial and Dental -- chapter 13 Opportunities in Spinal Applications.