Applied enzymology: an overview / Nancy Shanley and Gary Walsh -- Enzyme engineering / Barry M. McGrath -- Tissue plasminogen activator-based thrombolytic agents / Gary Walsh -- Activated protein C / Brian W. Grinnell, S. Betty Yan, and William L. Macias -- Deoxyribonuclease I / Niek N. Sanders, Stefaan C. de Smedt, and Joseph Demeester -- SS-glucocerebrosidase ceredase and cerezyme / Tim Edmunds -- A-galactosidase / Debra Barngrover -- Urate oxidase / Alain Bayol. [et al.] -- L-asparaginase review of pharmacology, drug resistance, and clinical applications / Christine Mauz-Korholz, Volker Wahn, and Dieter Korholz -- Recombinant factor VIIa / Elisabeth Erhardtsen. [et al.] -- Factor IX (protease zymogen) / Barry M. McGrath -- The development of aldurazyme (laronidase) / Emil Kakkis -- Additional therapeutic enzymes / Shane O'Connell.