chapter 1 Importance of the Interleukin-1ߖConverting Enzyme in Disease Mediated by the Proin?ammatory Cytokines IL-1 and IL-18 / chapter 2 Interleukin-10: A Cytokine with Multiple Anti- In?ammatory and Some Proin?ammatory Activities / chapter 3 Natural and Induced Anticytokine Antibodies in Humans / chapter 4 Anti-Tumor Necrosis Factor Therapies in Crohn's Disease and Rheumatoid Arthritis / chapter 5 Design and Development of Small-Molecule Inhibitor of Tumor Necrosis Factor-a / chapter 6 Screening and Design of Tumor Necrosis Factor-a: / chapter 7 Chemokine Receptors: Therapeutic Targets for Human Immunodeficiency Virus Infectivity / chapter 8 Receptor Antagonists of gp130 Signaling Cytokines / chapter 9 Negative-Feedback Regulations of Cytokine Signals / chapter 10 Inhibitors of the Janus Kinase�Signal Transducers and Activators of Transcription (JAK/STAT) Signaling Pathway / chapter 11 Inhibition of Vascular Endothelial Growth Factor (VEGF) and Stem-Cell Factor (SCF) Receptor Kinases as Therapeutic Targets for the Treatment of Human Diseases / chapter 12 p38 Inhibition