Machine generated contents note: Chapter 1 -- Interferon and the 2-5A/Pathway 1 -- Lionel Bastide, Edith Demettre, Camille Martinand-Mari, and Bernard Lebleu -- Chapter 2 -- Ribonuclease L: Overview of a Multifaceted Protein17 -- Patrick Englebienne, C. Vincent Herst, Simon Roelens, Anne D'Haese, -- Karim El Bakkouri, Karen De Smet, Marc Fremont, Lionel Bastide, Edith Demettre, -- and Bernard Lebleu -- Chapter 3 -- A 37-kDa RNase L: A Novel Form of RNase L Associated with Chronic Fatigue -- Syndrome55 -- Robert J. Suhadolnik, Susan E. Shetzline, Camille Martinand-Mari, and -- Nancy L. Reichenbach -- Chapter 4 -- Ribonuclease L Inhibitor: A Member of the ATP-Binding Cassette -- Superfamily73 -- Patrick Englebienne, C. Vincent Herst, Anne D'Haese, Kenny De Meirleir, Lionel -- Bastide, Edith Demettre, and Bernard Lebleu -- Chapter 5 -- The 2-5A Pathway and Signal Transduction: A Possible Link to Immune -- Dysregulation and Fatigue99 -- Patrick Englebienne, C. Vincent Herst, Marc Frimont, Thierry Verbinnen, -- Michel Verhas, and Kenny De Meirleir -- Chapter 6 -- Immune Cell Apoptosis and Chronic Fatigue Syndrome131 -- Marc Fremont, Anne D'Haese, Simon Roelens, Karen De Smet, C. Vincent Herst, -- and Patrick Englebienne -- Chapter 7 -- RNase L, Symptoms, Biochemistry of Fatigue and Pain, and Co-Morbid -- Disease175 -- Neil R. McGregor, Pascale De Becker, and Kenny De Meirleir -- Chapter 8 -- CFS Etiology, the Immune System, and Infection 201 -- Kenny De Meirleir, Pascale De Becker, Jo Nijs, Daniel L. Peterson, Garth Nicolson, -- Roberto Patarca-Montero, and Patrick Englebienne -- Chapter 9 -- Current Advances in CFS Therapy229 -- Pascale De Becker, Neil R. McGregor, Karen De Smet, and Kenny De Meirleir -- Chapter 10 -- From Laboratory to Patient Care265 -- Kenny De Meirleir, Daniel L. Peterson, Pascale De Becker, and -- Patrick Englebienne -- Index285.