chapter 1 What Is a Randomized Controlled Trial? -- chapter 2 Bias -- chapter 3 How Many Patients Do I Need? -- chapter 4 Methods of Allocation -- chapter 5 Assessment, Blinding, and Placebos -- chapter 6 Analysis of Results -- chapter 7 Further Analysis: Binary and Survival Data -- chapter 8 Monitoring Accumulating Data -- chapter 9 Subgroups and Multiple Outcomes -- chapter 10 Protocols and Protocol Deviations -- chapter 11 Some Special Designs: Crossovers, Equivalence, and Clusters -- chapter 12 Meta-Analyses of Clinical Trials.