chapter 1 The Motivation: A Top-Down View / chapter 2 Target Identification and Validation -- chapter 3 Functional Genomics / chapter 4 Integrated Proteomics Technologies / chapter 5 Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications / chapter 6 SNP Scoring for Drug Discovery Applications / chapter 7 Protein Display Chips / chapter 8 Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets / chapter 9 High-Throughput Screening as a Discovery Resource / chapter 10 Fluorescence Correlation Spectroscopy ( FCS) and FCS- Related Confocal Fluorimetric Methods ( FCS+ plus) -- chapter 11 Homogeneous Time-Resolved Fluorescence / chapter 12 ADME-Tox Screening in Drug Discovery / chapter 13 Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells / chapter 14 Miniaturization Technologies for High-Throughput Biology / chapter 15 Data Management for High-Throughput Screening / chapter 16 Combinatorial Chemistry: The History and the Basics / chapter 17 New Synthetic Methodologies / chapter 18 Supports for Solid-Phase Synthesis / chapter 19 The NMR “Toolkit” for Compound Characterization / chapter 20 Materials Management