Cover -- Title Page -- Copyright -- Dedication -- Contents -- List of Contributors -- About the Series Editors -- Preface -- Part I Enabling and Improving Large-Scale Bio-production -- Chapter 1 Industrial-Scale Fermentation -- 1.1 Introduction -- 1.2 Industrial-Scale Fermentation Today -- 1.3 Engineering and Design Aspects -- 1.4 Industrial Design Examples -- 1.5 Cost Analysis for the Manufacture of Biotechnological Products -- 1.6 Influence of Process- and Facility-Related Aspects on Cost Structure -- Acknowledgments -- References -- Chapter 2 Scale-Down: Simulating Large-Scale Cultures in the Laboratory -- 2.1 Introduction -- 2.2 Heterogeneities at Large Scale and the Need for Scaling Down -- 2.3 Bioreactor Scale-Down -- 2.4 Tools to Study Cell Responses to Environmental Heterogeneities -- 2.5 Physiological Effects of Environmental Heterogeneities -- 2.6 Improvements Based on Scale-Down Studies: Bioreactor Design and Cell Engineering -- 2.7 Perspectives -- Acknowledgment -- References -- Chapter 3 Bioreactor Modeling -- 3.1 Large-Scale Industrial Fermentations: Challenges for Bioreactor Modeling -- 3.2 Bioreactors -- 3.3 Compartment and Hybrid Multizonal/Computational Fluid Dynamics Approaches for the Description of Large-Scale Bioreactor Phenomena -- 3.4 Computational Fluid Dynamics Modeling: Unstructured Continuum Approach (Euler-Euler) -- 3.5 Computational Fluid Dynamics Modeling: Structured Segregated Approach (Euler-Lagrange) -- 3.6 Conclusion -- 3.7 Outlook -- References -- Chapter 4 Cell Culture Technology -- 4.1 Introduction -- 4.2 Overview of Applications for Cell Culture Products and Tissue Engineering -- 4.3 Fundamentals -- 4.4 Bioreactors for Cell Culture -- 4.5 Downstream -- 4.6 Regulatory and Safety Issues -- 4.7 Conclusions and Outlook -- References -- Part II Getting Out More: Strategies for Enhanced Bioprocessing.

Chapter 5 Production of Fuels and Chemicals from Biomass by Integrated Bioprocesses -- 5.1 Introduction -- 5.2 Utilization of Starchy Biomass -- 5.3 Utilization of Lignocellulosic Biomass -- 5.4 Conclusions and Perspectives -- Acknowledgment -- References -- Chapter 6 Solid-State Fermentation -- 6.1 Introduction -- 6.2 Fundamentals Aspects of SSF -- 6.3 Factors Affecting Solid-State Fermentation -- 6.4 Scale-Up -- 6.5 Product Recovery -- 6.6 Bioreactor Designing -- 6.7 Kinetics and Modeling -- 6.8 Applications -- 6.9 Challenges in SSF -- 6.10 Summary -- References -- Chapter 7 Cell Immobilization: Fundamentals, Technologies, and Applications -- 7.1 Introduction -- 7.2 Fundamentals of Cell Immobilization -- 7.3 Immobilization with Support Materials -- 7.4 Self-Immobilization -- 7.5 Immobilized Cells and their Applications -- 7.6 Bioreactors for Cell Immobilization -- 7.7 Challenges and Recommendations for Future Research -- 7.8 Conclusions -- References -- Part III Molecules for Human Use: High-Value Drugs, Flavors, and Nutraceuticals -- Chapter 8 Anticancer Drugs -- 8.1 Natural Products as Anticancer Drugs -- 8.2 Anticancer Drug Production -- 8.3 Important Anticancer Natural Products -- 8.4 Prospects -- References -- Chapter 9 Biotechnological Production of Flavors -- 9.1 History -- 9.2 Survey on Today's Industry -- 9.3 Regulations -- 9.4 Flavor Production -- 9.5 Biotechnological Production of Flavors -- 9.6 Vanillin -- 9.7 2-Phenylethanol -- 9.8 Benzaldehyde -- 9.9 Lactones -- 9.10 Raspberry Ketone -- 9.11 Green Notes -- 9.12 Nootkatone -- 9.13 Future Perspectives -- References -- Chapter 10 Nutraceuticals (Vitamin C, Carotenoids, Resveratrol) -- 10.1 Introduction -- 10.2 Vitamin C -- 10.3 Carotenoids -- 10.4 Resveratrol -- 10.5 Future Perspectives -- References -- Part IV Industrial Amino Acids.

Chapter 11 Glutamic Acid Fermentation: Discovery of Glutamic Acid-Producing Microorganisms, Analysis of the Production Mechanism, Metabolic Engineering, and Industrial Production Process -- 11.1 Introduction -- 11.2 Discovery of the Glutamic Acid-Producing Bacterium C. glutamicum -- 11.3 Analysis of the Mechanism of Glutamic Acid Production by C. glutamicum -- 11.4 Metabolic Engineering of C. glutamicum for Glutamic Acid Production -- 11.5 Glutamic Acid Fermentation by Other Microorganisms -- 11.6 Industrial Process of Glutamic Acid Production -- 11.7 Future Perspectives -- References -- Chapter 12 l-Lysine -- 12.1 Uses of l-Lysine -- 12.2 Biosynthesis and Production of l-Lysine -- 12.3 The Chassis Concept: Biotin Prototrophy and Genome Reduction -- 12.4 l-Lysine Biosensors for Strain Selection and on-Demand Flux Control -- 12.5 Perspective -- References -- Part V Bio-Based Monomers and Polymers -- Chapter 13 Diamines for Bio-Based Materials -- 13.1 Introduction -- 13.2 Diamine Metabolism in Bacteria -- 13.3 Putrescine -- 1,4-Diaminobutane -- 13.4 Cadaverine -- 1,5-Diaminopentane -- 13.5 Conclusions and Perspectives -- References -- Chapter 14 Microbial Production of 3-Hydroxypropionic Acid -- 14.1 Introduction -- 14.2 3-HP Obtained from Native Producers -- 14.3 Synthesis of 3-HP from Glucose -- 14.4 Synthesis of 3-HP from Glycerol -- 14.5 Bridging the Gap Between Glucose and Glycerol in 3-HP Production -- 14.6 Other Strains for 3-HP Production from Glycerol -- 14.7 Limitations of 3-HP Synthesis -- 14.8 Conclusions and Future Prospects -- Acknowledgments -- References -- Chapter 15 Itaconic Acid -- An Emerging Building Block -- 15.1 Background, History, and Economy -- 15.2 Biosynthesis of Itaconic Acid -- 15.3 Production Conditions for Itaconic Acid -- 15.4 Physiological Effects and Metabolism of Itaconic acid.

15.5 Metabolic Engineering for Itaconic Acid Production -- 15.6 Outlook -- Acknowledgments -- References -- Part VI Top-Value Platform Chemicals -- Chapter 16 Microbial Production of Isoprene: Opportunities and Challenges -- 16.1 Introduction -- 16.2 The Milestones of Isoprene Production -- 16.3 Microbial Production of Isoprene: Out of the Laboratory -- 16.4 Main Challenges for Bioisoprene Production -- 16.5 Future Prospects -- Acknowledgments -- References -- Chapter 17 Succinic Acid -- 17.1 Introduction -- 17.2 Development of Succinic Acid Producers and Fermentation Strategies -- 17.3 Succinic Acid Recovery and Purification -- 17.4 Summary -- Acknowledgments -- References -- Part VII Biorenewable Fuels -- Chapter 18 Ethanol: A Model Biorenewable Fuel -- 18.1 Introduction -- 18.2 Metabolic Engineering: Design, Build, Test, Learn -- 18.3 Biomass Deconstruction -- 18.4 Closing Remarks -- Acknowledgments -- References -- Chapter 19 Microbial Production of Butanols -- 19.1 Introduction -- 19.2 A Historical Perspective of n-Butanol Production -- 19.3 ABE Fermentation -- 19.4 n-Butanol Production in Non-native Producers -- 19.5 Isobutanol Production -- 19.6 Summary and Outlook -- Acknowledgments -- References -- Index -- EULA.