Front Matter -- Introduction. Karen J. Brewer (1961-2014) / Seth C Rasmussen -- Basic Coordination Chemistry of Ruthenium / Mark A W Lawrence, Jimmie L Bullock, Alvin A Holder -- Artificial Photosynthesis. Water Oxidation Catalysis with Ruthenium / Andrea Sartorel -- Ruthenium- and Cobalt-Containing Complexes and Hydrogenases for Hydrogen Production / Michael J Celestine, Raj K Gurung, Alvin A Holder -- Applications in Medicine. Ligand Photosubstitution Reactions with Ruthenium Compounds / Samantha L Hopkins, Sylvestre Bonnet -- Use of Ruthenium Complexes as Photosensitizers in Photodynamic Therapy / Lothar Lilge -- Photodynamic Therapy in Medicine with Mixed-Metal/Supramolecular Complexes / Jimmie L Bullock, Alvin A Holder -- Ruthenium Anticancer Agents En Route to the Tumor / Muhammad Hanif, Christian G Hartinger -- Design Aspects of Ruthenium Complexes as DNA Probes and Therapeutic Agents / Madeleine De Beer, Shawn Swavey -- Ruthenium-Based Anticancer Compounds: Insights into Their Cellular Targeting and Mechanism of Action / António Matos, Filipa Mendes, Andreia Valente, Tânia Morais, Ana Isabel Tomaz, Philippe Zinck, Maria Helena Garcia, Manuel Bicho, Fernanda Marques -- Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes / Martin R Gill, Jim A Thomas -- Biological Activity of Ruthenium Complexes With Quinoline Antibacterial and Antimalarial Drugs / Jakob Kljun, Iztok Turel -- Ruthenium Complexes as NO Donors / Loyanne CB Ramos, Juliana C Biazzotto, Juliana A Uzuelli, Renata G Lima, Roberto S Silva -- Trends and Perspectives of Ruthenium Anticancer Compounds (Non-PDT) / Michael A Jakupec, Wolfgang Kandioller, Beatrix Schoenhacker-Alte, Robert Trondl, Walter Berger, Bernhard K Keppler -- Ruthenium Complexes as Antifungal Agents / Claudio L Donnici, Maria H Araujo, Maria A R Stoianoff -- Index.