Introduction: The Case for Concern about Mutation and Cancer Susceptibility during Critical Windows of Development and the Opportunity to Translate Toxicology into a Therapeutic Discipline. What Stressors Cause Cancer and When? / Claude L Hughes, Michael D Waters -- What Mutagenic Events Contribute to Human Cancer and Genetic Disease? / Michael D Waters -- Developmental Origins of Cancer / Suryanarayana V Vulimiri, John M Rogers -- The Mechanistic Basis of Cancer Prevention / Bernard W Stewart -- Exposures that Could Alter the Risk of Cancer Occurrence, and Impact Its Indolent or Aggressive Behavior and Progression Over Time. Diet Factors in Cancer Risk / Lynnette R Ferguson -- Voluntary Exposures: Natural Herbals, Supplements, and Substances of Abuse -- What Evidence Distinguishes Therapeutic from Adverse Responses? / Eli P Crapper, Kylie Wasser, Katelyn J Foster, Warren G Foster -- Voluntary Exposures: Pharmaceutical Chemicals in Prescription and Over-the-Counter Drugs -- Passing the Testing Gauntlet / Ronald D Snyder -- Children's and Adult Involuntary and Occupational Exposures and Cancer / Annamaria Colacci, Monica Vaccari -- Gene-Environment Interactions. Ethnicity, Geographic Location, and Cancer / Fengyu Zhang -- Dietary/Supplemental Interventions and Personal Dietary Preferences for Cancer: Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Sandeep Kaur, Elaine Trujillo, Harold Seifried -- Social Determinants of Health and the Environmental Exposures: A Promising Partnership / Lauren Fordyce, David Berrigan, Shobha Srinivasan -- Categorical and Pleiotropic Nonmutagenic Modes of Action of Toxicants: Causality. Bisphenol A and Nongenotoxic Drivers of Cancer / Natalie R Gassman, Samuel H Wilson -- Toxicoepigenetics and Effects on Life Course Disease Susceptibility / Luke Montrose, Jaclyn M Goodrich, Dana C Dolinoy -- Tumor-Promoting/Associated Inflammation and the Microenvironment: A State of the Science and New Horizons / William H Bisson, Amedeo Amedei, Lorenzo Memeo, Stefano Forte, Dean W Felsher -- Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology / R Brooks Robey -- Biomarkers for Detecting Premalignant Effects and Responses to Protective Therapies during Critical Windows of Development. Circulating Molecular and Cellular Biomarkers in Cancer / Ilaria Chiodi, A Ivana Scovassi, Chiara Mondello -- Global Profiling Platforms and Data Integration to Inform Systems Biology and Translational Toxicology / Barbara A Wetmore -- Developing a Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction / Rebecca Johnson, David Kerr -- Ethical Considerations in Developing Strategies for Protecting Fetuses, Neonates, Children, and Adolescents from Exposures to Hazardous Environmental Agents / David B Resnik, Melissa J Mills.