"This book provides the state-of-the-art in methods and technologies that aim to elaborate on the modeling and simulation support to CPS engineering across many sectors such as healthcare, smart grid or smart home. The book presents a compilation of simulation-based methods, technologies and approaches that encourage the reader to incorporate simulation technologies in their CPS engineering endeavors, supporting management of complexity challenges in such endeavors. There are three main elements to this: first, review of the state-of-the-art methods M & S and CPS paradigms; second, identification and/or proposition of technological support for linkages within M & S hybrid models and between M & S models and CPS structures; third, the proposition of frameworks for using M & S/CPS co-simulation for complex systems (e.g. healthcare) by way of a research roadmap"-- Provided by publisher.