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Cobalt catalysis in organic synthesis : methods and reactions

Hapke, Marko, editor.

Cobalt catalysis in organic synthesis : methods and reactions

Hapke, Marko, editor.

9783527814855

9783527814831

9783527814862

Weinheim : Wiley-VCH, 2020.

1 online resource (483 pages) : illustrations

Chapter 5 Low-valent Cobalt Complexes in C-X Coupling and Related Reactions

Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 Introduction to Cobalt Chemistry and Catalysis -- 1.1 Introduction -- 1.2 Organometallic Cobalt Chemistry, Reactions, and Connections to Catalysis -- 1.2.1 Cobalt Compounds and Complexes of Oxidation States +3 to -1 -- 1.2.1.1 Co(III) Compounds -- 1.2.1.2 Co(II) Compounds -- 1.2.1.3 Co(I) Compounds -- 1.2.1.4 Co(0) Compounds -- 1.2.1.5 Co( -I) Compounds -- 1.2.2 Bioorganometallic Cobalt Compounds -- 1.3 Applications in Organic Synthesis and Catalytic Transformations -- 1.4 Conclusion and Outlook -- Abbreviations -- References

Chapter 2 Homogeneous Cobalt-Catalysed Hydrogenation Reactions -- 2.1 Introduction -- 2.2 Hydrogenation of C C Multiple Bonds (Alkenes, Alkynes) -- 2.3 Hydrogenation of Carbonyl Compounds (Ketones, Aldehydes, Carboxylic Acid Derivatives, CO2) -- 2.3.1 Ketones and Aldehydes -- 2.3.2 Carboxylic Acid Derivatives (Acids, Esters, Imides) -- 2.3.3 Hydrogenation of Carbon Dioxide -- 2.4 Hydrogenation of C X Multiple Bonds (Imines, Nitriles) -- 2.4.1 Nitrile Hydrogenation -- 2.4.2 Imine Hydrogenation -- 2.4.3 Hydrogenation of N-Heterocycles -- 2.5 Summary and Conclusions

2.6 Selected Experimental Procedures -- 2.6.1 Synthesis of Cobalt Complex [(PNHPCy)Co(CH2SiMe3)]BArF4 (8a) -- Abbreviations -- References -- Chapter 3 Synthesis of C C Bonds by Cobalt-Catalysed Hydrofunctionalisations -- 3.1 Introduction -- 3.2 Cobalt-Catalysed C C Bond Formations via Hydrofunctionalisation -- 3.2.1 Hydroformylation -- 3.2.2 Hydroacylation -- 3.2.3 Hydrovinylation -- 3.2.4 Hydroalkylation -- 3.2.5 Hydrocyanation -- 3.2.6 Hydrocarboxylation -- 3.3 Summary and Conclusions -- Abbreviations -- References -- Chapter 4 Cobalt-Catalysed C-H Functionalisation -- 4.1 Introduction

4.2 Low-valent Cobalt Catalysis -- 4.2.1 C-H Functionalisation with In Situ-Reduced Cobalt Catalysts -- 4.2.1.1 Hydroarylation of Alkynes and Alkenes -- 4.2.1.2 C-H Functionalisation with Electrophiles -- 4.2.1.3 C-H Functionalisation with Organometallic Reagents -- 4.2.1.4 C-H Functionalisation via 1,4-Cobalt Migration -- 4.2.1.5 Hydroacylation -- 4.2.2 C-H Functionalisation with Pincer-Type Ligands and Related Well-Defined Cobalt Catalysts -- 4.3 High-valent Cobalt Catalysis -- 4.3.1 Chelation-Assisted C-H Functionalisation with Cp*CoIII Catalysts -- 4.3.1.1 C H Addition to Polar C X Bonds

4.3.1.2 Reaction with Alkynes, Alkenes, and Allenes -- 4.3.1.3 Reaction with Formal Nitrene or Carbene Precursors -- 4.3.1.4 Reaction with E-X-type Electrophiles -- 4.3.1.5 Miscellaneous -- 4.3.2 Bidentate Chelation-Assisted C-H Functionalisation with CoIII Catalysts -- 4.3.2.1 Reaction with Alkynes, Alkenes, and Allenes -- 4.3.2.2 Dehydrogenative Cross-coupling Reactions -- 4.3.2.3 Carbonylation and Related Transformations -- 4.3.2.4 Miscellaneous Transformations -- 4.3.3 Miscellaneous -- 4.4 Summary and Outlook -- Abbreviations -- References

Provides a much-needed account of the formidable "cobalt rush" in organic synthesis and catalysis Over the past few decades, cobalt has turned into one of the most promising metals for use in catalytic reactions, with important applications in the efficient and selective synthesis of natural products, pharmaceuticals, and new materials. Cobalt Catalysis in Organic Synthesis: Methods and Reactions provides a unique overview of cobalt-catalysed and -mediated reactions applied in modern organic synthesis. It covers a broad range of homogeneous reactions, like cobalt-catalysed hydrogenation, hydrofunctionalization, cycloaddition reactions, C-H functionalization, as well as radical and biomimetic reactions. First comprehensive book on this rapidly evolving research area Covers a broad range of homogeneous reactions, such as C-H activation, cross-coupling, synthesis of heterocyclic compounds (Pauson-Khand), and more Chapters on low-valent cobalt complexes as catalysts in coupling reactions, and enantioselective cobalt-catalyzed transformations are also included Can be used as a supplementary reader in courses of advanced organic synthesis and organometallic chemistry Cobalt Catalysis in Organic Synthesis is an ideal book for graduates and researchers in academia and industry working in the field of synthetic organic chemistry, catalysis, organometallic chemistry, and natural product synthesis.

John Wiley and Sons

Cobalt catalysts.

Organic compounds -- Synthesis.

Catalyseurs au cobalt.

Composés organiques -- Synthèse.

Materials Science.

TECHNOLOGY & ENGINEERING.

Cobalt catalysts

Organic compounds -- Synthesis

Electronic books.

Hapke, Marko,

Hilt, Gerhard,

https://onlinelibrary.wiley.com/doi/book/10.1002/9783527814855