"The pace of change in the field of pediatric hematology, oncology and hematopoietic cell therapies is staggering. Molecular biology, genomics, and biochemistry have accelerated knowledge and understanding of disease states and further highlight the complex interplay of clinical, genetic and social factors which constantly challenge us in the rapid application of novel findings to treat patients with the goal of improved outcomes. This translation of knowledge to the unique patient before us, the true art of the physician, encompassing experience, knowledge, intuition and understanding of the individual needs and goals of patients and families, can be overwhelming. What is needed is a practical, tested approach to analyze and address these problems to ensure a timely evaluation, competent clinical care, and avoidance of pitfalls that might negatively impact the patient or future treatment options. This practical approach is achieved by spending time with patients and families and observing the myriad variations in disease and individual nuances that are not addressed in large studies or case reports all the while expanding foundational knowledge"-- Provided by publisher.