Intro -- Impact of Engineered Nanomaterials in Genomics and Epigenomics -- Contents -- List of Contributors -- Preface -- Acknowledgments -- 1 Impact of Engineered Nanomaterials in Genomics and Epigenomics -- Nanotechnology: A Technological Advancement of the Twenty-First Century -- Genomics and Epigenomics -- Beneficial Impacts of Engineered Nanomaterials on Human Life -- Potential Adverse Health Effects of Engineered Nanomaterials -- Conclusions -- References -- 2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels -- Introduction -- Classification of NMs -- Absorption and Distribution of NMs -- Inhalation Exposure -- Oral Exposure -- Dermal Exposure -- Circulatory Distribution -- Accumulation of NMs in Organs -- Major Adverse Effects of NMs -- Known Cellular and Nuclear Uptake Mechanisms for Nanoparticles -- Epigenetic Mechanisms and the Effect of NMs -- DNA Methylation -- Histone Modification -- Noncoding RNAs -- Genetic and Genomic Effects of NMs -- Genetic Damage (Genotoxicity) -- Genomic Changes on the Messenger RNA Level -- Conclusion -- References -- 3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways -- Introduction -- Toxic Effects of EDCs on Wildlife and Humans -- EDCs Effects on Wildlife -- Effects During Development -- Delayed Effects -- Transgenerational Effects -- Identification of EDC: Methods -- Genetic Pathways -- Nuclear Receptor-Mediated Assays -- Phosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC -- ER-Signaling Pathways -- Xenoandrogens and Metabolic Syndrome -- AR Signaling Pathways -- Mechanism of ED -- Epigenetic Mechanism -- Methylation and Gene Regulation -- Role of Noncoding RNAs -- Transgenerational Inheritance of Epigenetics Induced by EDCs -- Anti-Thyroids -- Organotin -- Genomic Signaling and Effects.

Epigenetic Effects of Organotin -- TCDD and Related Compounds -- TCDD and Genetic Response -- TCDD-Mediated Epigenetic Response -- Conclusions -- References -- 4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation -- Introduction -- Fate and Behavior of NPs in Agroecosystem and Soil Environment -- Uptake and Accumulation of NPs in Plants -- NPs and Phytotoxicity -- Morphological and Physiological Responses -- Biochemical and Metabolic Responses -- Can NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? -- NPs Cause Cytogenotoxicity -- NPs and Epigenetic Regulation -- Conclusion and Perspectives -- References -- 5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects -- Introduction -- Physicochemical Properties of NMs and Toxicity -- Mechanism of NM Genotoxicity -- Epigenetic Effects of Nanomaterials -- Studies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials -- Titanium Dioxide NPs -- Zinc Oxide NPs -- Silver and Silver Oxide NPs -- Copper and Copper Oxide NPs -- Cobalt Oxide Nanoparticles -- Silicon Dioxide NPs -- Graphene-Based NMs -- Studies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials -- Metal Oxide Nanomaterials -- Graphene-Based Nanomaterials -- Studies on Workers -- Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials -- Conclusions -- References -- 6 Epigenotoxicity of Titanium Dioxide Nanoparticles -- Introduction -- Cellular Uptake and Biodistribution -- DNA Methylation and TiO2 Nanoparticles -- Histone Modifications and TiO2 Nanoparticles -- MicroRNAs and TiO2 Nanoparticles -- Risk Assessment -- Conclusion -- Disclaimer -- References.

7 Toxicogenomics of Multi-Walled Carbon Nanotubes -- Introduction -- MWCNTs -- Lung Injury -- Inflammation -- Oxidative Stress -- Fibrosis -- Mesothelioma -- Lung Cancer -- Genotoxicity -- Toxicogenomics of ENMs -- Transcriptomics -- Technical Aspects -- Toxicogenomics of MWCNTs -- Animal Studies -- Toxicogenomics of MWCNT -- Human Studies -- Disclaimer -- References -- 8 Nano-Engineering in Traumatic Brain Injury -- Introduction -- Nanoparticles in the Treatment of TBI -- Synthesis of Nanoparticles -- Mechanisms of Action of Nanoparticles in TBI -- Materials Used for the Synthesis of NPs in TBI Treatment -- Limitations of the Use of NPs in TBI Therapy -- Conclusion -- References -- 9 Application of Nanoemulsions in Food Industries: Recent Progress, Challenges, and Opportunities -- Introduction -- Components of Nanoemulsions -- Oil Phase -- Aqueous Phase -- Stabilizers -- Approaches for Nanoemulsion Production -- High-Energy Approaches -- Low-Energy Approaches -- Novel Approach for the Production of Nanoemulsion -- Applications of Food-Grade Nanoemulsions -- Encapsulation of Lipophilic Functional Food -- Expansion of the Functional Food Sector for the Application of Edible Coatings with Lipophilic Bioactive Substances -- Invasion of Nanotechnology and Emulsion in Food Ingredients and Additives -- Purple Rice Bran Oil Nanoemulsion Fortification of Frozen Yogurt -- Formation of Various Phytosomes and Using Them for Delivery in Herbal Products Without Resorting to Pharmacological Adjuvants -- Food Packaging -- Use in Confectionary -- Comparison of Nanoemulsion from Conventional Methods -- Problems and Probable Solutions of Nanoemulsions -- Future Trends and Challenges -- Regulations and Safety Aspects -- Conclusion -- Conflict of Interest -- Acknowledgments -- References.

10 Adverse Epigenetic Effects of Environmental Engineered Nanoparticles as Drug Carriers -- Introduction -- ENP-Based Drug-Delivery Systems -- Lipid-Based ENPs -- Polymeric ENPs -- Inorganic ENPs -- Adverse Epigenetic Effects of ENPs -- Overview of Epigenetic Toxicity of ENPs -- Epigenetic Toxicity of Metallic ENPs -- Epigenetic Toxicity of Nonmetallic ENPs -- ENP-Induced Epigenetic Toxicity Likely Mediated by ROS -- Conclusion -- References -- 11 Engineered Nanoparticles Adversely Impact Glucose Energy Metabolism -- Introduction -- Biological Toxicity of Engineered Nanoparticles -- Engineered Nanoparticles Alter Glucose Metabolism -- Engineered Nanoparticles Alter TCA Cycle -- Engineered Nanoparticles Alter Oxidative Phosphorylation -- Conclusion -- References -- 12 Artificial Intelligence and Machine Learning of Single-Cell Transcriptomics of Engineered Nanoparticles -- Introduction -- Impact of Nanoparticles on Single-Cell Transcriptomics and Response Heterogeneity -- Overview of Engineered Nanoparticles -- Dose-Dependent Heterogeneous Transcriptomic Responses to Quantum Dots -- TiO2 Nanoparticles of Different Sizes Elicit Heterogeneous Transcriptomic Responses -- AI and ML in scRNA-Seq Data Analysis -- Overview of AI and ML in Bioinformatics -- MRF in Differential Expression Analysis of scRNA-Seq Data -- Deep Learning for Inferring Gene Relationships from scRNA-Seq Data -- Determining Cell Differentiation and Lineage Based on Single-Cell Entropy -- Conclusion -- References -- 13 Toxicogenomics and Toxicological Mechanisms of Engineered Nanomaterials -- Introduction -- Genomic Responses to ENMs -- Transcriptomic Responses to ENMs -- Conclusion -- References -- 14 Carbon Nanotubes Alter Metabolomics Pathways Leading to Broad Ecological Toxicity -- Introduction -- Biomedical Application and Toxicity of Carbon Nanotubes.

Single-Walled Carbon Nanotubes -- Multi-Walled Carbon Nanotubes -- Metabolomics Toxicity of Carbon Nanotubes -- A Brief of Metabolomic Techniques Used for CNT Toxicity Profiling -- NMR-Based Metabolomic Profiling -- LC-MS-Based Metabolomic Profiling -- Conclusion -- References -- 15 Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry-Based MultiOmics Approaches -- Introduction -- Applications of MS for the Measurements of Proteins, PTMs, Lipids, and Metabolites -- Multiomics Investigation of ENM Exposure to Microorganisms -- Multiomics Investigation of ENM Exposure Using In Vitro Cell Culture Models -- Analysis of ENM Toxicity in Liver-Based Cell Models -- Macrophage-Based Studies of ENM Toxicity -- Neuronal Cell Models Reveal Potential Mechanisms of ENM-Induced Neurotoxicity -- Multiomics Studies Reveal Organ-Specific Toxicity at the Organismal Level -- Mechanisms of ENM-Induced Toxicity in the Lung -- Elucidation of Response Pathways Following Ingestion of ENMs -- ENM-Induced Metabolic Changes in the Gut: Involvement of Multiple Biological Systems -- ENM-Induced Metabolic Changes During Embryo Development -- Probing the Relationship Between Particle Size and Toxicity in Whole Animal Systems -- Conclusions and Perspectives -- Acknowledgments -- Compliance with Ethical Standards -- References -- 16 Current Scenario and Future Trends of Plant Nano-Interaction to Mitigate Abiotic Stresses: A Review -- Abbreviations -- Introduction -- Synthesis of Nanoparticles -- Silver Nanoparticles -- Aluminum Oxide Nanoparticles -- Copper Nanoparticles -- Iron Nanoparticles -- Carbon Nanoparticles -- Synthesis of Other Metal Nanoparticles -- Morphophysiological Effects of Nanoparticles on Plant -- Arabidopsis -- Rice -- Soybean -- Wheat -- Other Plants -- Molecular Mechanism Altered by Nanoparticles -- Oxidative Stresses.