Safeguard your operational integrity and data reliability with this essential technical and investigative guide, which critically examines and provides actionable frameworks to combat the dangerously undercommunicated risks of calibration drift and systemic measurement failures across all industries. As industries grow more complex and digitized, the demand for precision and reproducibility has escalated, placing extraordinary reliance on sensors, analytical instruments, and automated data systems. This evolution has exposed systemic vulnerabilities such as outdated calibration protocols, unvalidated assumptions, and fragmented oversight across lifecycle stages. This book is a technical and investigative work that critically examines the overlooked, misunderstood, and dangerously undercommunicated issues of calibration drift, traceability loss, and systemic measurement failures across science, engineering, and industry. The book provides a structured, in-depth exploration of how calibration standards shift without timely notification and the cascading consequences this can have on data reliability, regulatory compliance, safety, and decision-making. The content spans from foundational concepts in calibration and metrology to detailed technical analyses of failure modes in sensors, instruments, and analytical systems. The book emphasizes the interconnectedness of human factors, systemic inertia, and institutional resistance to change, delivering actionable frameworks for building resilience, including updated ISO standards, failure mode and effects analysis, checklists, dashboards, and protocols.