The Irreversibility of Organ Injury -- Nonregenerative Tissues -- Experimental Methods I. The Anatomically Well-Defined Wound -- Experimental Methods II. The Defect Closure Rule -- Regeneration of Skin -- Regeneration of a Peripheral Nerve -- Minimum Reactants Required for Synthesis of Skin and Peripheral Nerves; Extension to Tissues of Other  Organs -- An Antagonistic Relation Between Wound Contraction and Regeneration -- Molecular biology of contraction blockade by active scaffolds -- The Scaffold Regeneration Paradigm and its Consequences.