Preface -- Part I From Hypotheses to Mechanisms -- Part II Human Longevity: Centenarianism and Progeria -- Part III Stem Cells, Cultured Neurons, and Lower Animal Models -- Part IV Metabolism: Factors Affecting Tissue Aging -- Part V Aging Brain: Adult Neurogenesis, Synaptic Plasticity, and Brain Volume -- Part VI Aged Brain: Mechanisms of Neurodegeneration -- Part VII Anti-Brain Aging: Neuroprotection and Therapeutic Approaches -- Epilogue -- Appendix -- Index.  .