Epidemiology of lung cancer. Biology of preneoplastic lesions. Pathology of preneoplastic lesions. Spiral CT for screening and early detection. New methods for bronchoscopic detection. The role of sputum examination for screening and early detection. What is the optimal target population for screening and early detection programs. Primary prevention including smoking cessation. Chemoprevention of lung cancer. Treatment of early detected lung cancer. International organization of screening programs.