chapter 1 Clinical Manifestations, Natural History, and Differential Diagnosis of Re?ux Esophagitis / chapter 2 Risk Factors for Gastroesophageal Re?ux Disease: Types and Mechanisms -- John David Horwhat and Roy K. H. Wong / chapter 3 Epidemiology of Gastroesophageal Re?ux Disease / chapter 4 Diagnostic Tests for Gastroesophageal Re?ux Disease / chapter 5 Pathophysiology of Gastroesophageal Re?ux Disease: The Antire?ux Barrier and -- Peter J. Kahrilas and Guoxiang Shi / chapter 6 Pathophysiology of Gastroesophageal Re?ux Disease: Offensive Factors and Tissue Resistance -- Roy C. Orlando / chapter 7 Esophageal Complications (Other Than Barrett's) of Gastroesophageal Re?ux Disease / chapter 8 Barrett's Esophagus / chapter 9 Extraesophageal Complications of Gastroesophageal Re?ux Disease: Epidemiology, Natural History, Pathogenesis, Diagnosis, and Management -- Walter J. Hogan and Reza Shaker / chapter 10 Medical Therapy of Gastroesophageal Re?ux Disease / chapter 11 Surgical Treatment of Gastroesophageal Re?ux Disease / chapter 12 Gastroesophageal Re?ux Disease in Infants and Children