chapter 1 Dioxygen Activation by Cytochromes P450: A Role for Multiple Oxidants in the Oxidation of Substrates -- chapter 2 Application of LC/MS, LC/NMR, NMR and Stable Isotopes in Identifying and Characterizing Metabolites -- chapter 3 Bioactivation / chapter 4 CHEMICALLY REACTIVE METABOLITES IN DRUGDISCOVERY AND DEVELOPMENT -- chapter 5 Cytochrome P450 and its Place in Drug Discovery and Development -- chapter 6 Cytochrome P450 in Laboratory Animal Species / chapter 7 Typical and Atypical Enzyme Kinetics / chapter 8 Cytochrome P450 Reaction Phenotyping / chapter 9 Drug-Drug Interactions and the Cytochromes P450 -- chapter 10 CYP Gene Induction by Xenobiotics and Drugs -- chapter 11 Cytochrome P450 Pharmacogenetics / chapter 12 Role of Intestinal Cytochromes P450 in Drug Disposition -- chapter 13 Prediction of Hepatic Clearance in Humans from Experimental Animals and In Vitro Data -- chapter 14 Non-P450 Mediated Oxidative Metabolism of Xenobiotics -- chapter 15 THE ROLE OF SULFOTRANSFERASES (SULTS) AND UDP- GLUCURONOSYLTRANSFERASES (UGTS) IN HUMAN DRUG CLEARANCE AND BIOACTIVATION.