part Part 1. Basic Science -- chapter 1 Part 1. Basic Science Pharmacological Effects of Nicotine and Nicotinic Receptor Subtype Pharmacological Profiles -- chapter 2 Cellular and Synaptic Effects of Nicotine -- chapter 3 Animal Models of Nicotine Addiction: Implications for Medications Development -- part Part 2. First-Line Medication Treatments -- chapter 4 Nicotine Replacement Therapies and Other Nicotinic Strategies -- chapter 5 Sustained-Release Bupropion as a Pharmacological Aid to Smoking Cessation -- part Part 3. Second-Line Medication Treatments -- chapter 6 Tricyclic Antidepressants in the Treatment of Nicotine Dependence -- chapter 7 Monoamine Oxidase Inhibitors for Smoking Cessation -- chapter 8 Opioid Antagonists for the Treatment of Nicotine Dependence -- chapter 9 Other Nonapproved Agents for Smoking Cessation -- part Part 4. Novel Medication Treatments -- chapter 10 Immunological Approaches to Nicotine Addiction -- chapter 11 Glutamatergic Agents for Nicotine Dependence -- chapter 12 GABAergic Agents for the Treatment of Nicotine Dependence -- chapter 13 Cannabinoid Antagonists: CB1 Receptors as a Therapeutic Target for Nicotine Dependence -- chapter 14 Targeting the Dopamine D3 Receptor for Treatment of Nicotine Dependence -- chapter 15 Varenicline: An α4β2 Nicotinic Acetylcholine Receptor Partial Agonist as an Aid to Smoking Cessation -- part Part 5. Special Topics -- chapter 16 Combining Medications with Behavioral Treatments -- chapter 17 Medication Treatments for Nicotine Dependence in Psychiatric and Substance Use Disorders -- chapter 18 Pharmacogenetic Approaches to the Treatment of Nicotine Dependence -- chapter 19 Neuroimaging of Nicotine Dependence: A Bioassay for Medications Development -- part Part 6. Concluding Prespectives -- chapter 20 Suggestions for Future Research -- chapter 21 Treatment of Nicotine Dependence: Toward a Partial Solution.