chapter 1 Introduction -- chapter 2 The importance of the physicochemical properties of drugs to drug metabolism -- David Spalding -- chapter 3 Sample preparation -- Glenn Smith -- chapter 4 High-performance liquid chromatography in pharmaceutical bioanalysis -- David N. Mallett -- chapter 5 Mass spectrometry and quantitative bioanalysis -- Callejas and Gary Evans -- chapter 6 Immunoassay in pharmacokinetic and pharmacodynamic bioanalysis -- Richard Nicholl, Paul Linacre and Bill Jenner -- chapter 7 Pre-clinical pharmacokinetics -- Sheila Schwartz and -- chapter 8 Pharmacokinetic/ pharmacodynamic modelling in pre-clinical drug discovery -- chapter 9 Toxicokinetics -- Sheila Schwartz -- chapter 10 Protein binding in plasma: a case history of a highly protein-bound drug -- Robert J. Barnaby and Marco Bottacini -- chapter 11 Isotope drug studies in man -- Graeme Young, John Ayrton and Tony Pateman -- chapter 12 Whole body autoradiography -- Brouwer and Jeanne Jarrett -- chapter 13 Phase I metabolism -- Peter Eddershaw and Maurice Dickins -- chapter 14 Phase II enzymes -- Dickins and Elizabeth Pickup -- chapter 15 In vitro techniques for investigating drug metabolism -- Graham Somers, Peter Mutch and Amanda Woodrooffe -- chapter 16 Drug�drug interactions: an in vitro approach -- chapter 17 Identification of drug metabolites in biological fluids using qualitative spectroscopic and chromatographic techniques -- chapter 18 Molecular biology -- Steve Hood -- chapter 19 The role of drug metabolism and pharmacokinetics in drug discovery: past, present and future.