chapter 1 1 -- chapter 2 Temperature Effects in Liquid Chromatography -- chapter 3 Lipophilicity Measurements by Liquid Chromatography -- chapter 4 Concepts and Practice of Multidimensional High-Performance Liquid Chromatography -- chapter 5 High-Performance Liquid Chromatography in the Pharmaceutical Industry: Application, Validation, and Regulatory Issues Under the PAT Framework -- chapter 6 The Use of Polysaccharide Phases in the Separation of Enantiomers -- chapter 7 Chaotropic Effects in RP-HPLC -- chapter 8 Chromatography of Difficult and Water-Insoluble Proteins with Organic Solvents.