chapter 1 Introduction: Free Radical Damage versus Free Radical Signaling -- chapter 2 Free Radical Signaling in Reactions Catalyzed by Enzymes—Producers of Reactive Oxygen and Nitrogen Species -- chapter 3 3Chapter Reactive Oxygen and Nitrogen Species Signaling in Mitochondria -- chapter 4 4Chapter ROS and RNS Signaling in Catalysis of Heterolytic Reactions by Kinases, Phosphatases, and Other Enzymes -- chapter 5 5Chapter ROS and RNS Signaling in Apoptosis -- chapter 6 6Chapter ROS and RNS Signaling in Senescence and Aging -- chapter 7 Mechanisms of ROS and RNS Signaling in Enzymatic Catalysis.