1. Introduction to modelling and simulation -- 2. An overview of modelling and simulation -- 3. Models based on simple laws -- 4. Models based on laws of conservation -- 5. Multiphase systems without reaction -- 6. Multiphase systems with reaction -- 7. Population balance models and discrete-event models -- 8. Artificial neural network-based models -- 9. Model validation and sensitivity analysis -- 10. Case studies -- 11. Simulation of large plants.