chapter 1 Introduction and Historical Perspective -- chapter 2 Three-Dimensional Protein Structures of Light Chains of Botulinum Neurotoxin Serotypes A, B, and E and Tetanus Neurotoxin -- chapter 3 Mechanisms of Actions of Neurotoxins -- chapter 4 Vaccines to Protect against Neurotoxins* -- chapter 5 Inhibitors of Clostridial Neurotoxin Proteinase Activities -- chapter 6 Introduction to Clinical Use of Botulinum Neurotoxins -- chapter 7 Expanding Clinical Uses of Botulinum Neurotoxins -- chapter 8 Development of Therapeutics Based upon Clostridial Endopeptidase Activity -- chapter 9 Use of Neurotoxins as Drug Delivery Systems -- chapter 10 Conclusions and Future Perspectives: Botulinum Neurotoxins as Paradigms for Development of Microbial Effector- Derived Drugs.