chapter 1 Chapter Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery -- chapter 2 Chapter The Drug Discovery Process: From Molecules to Drugs -- chapter 3 Chapter PK Principles and PK/PD Applications -- chapter 4 Chapter Mass Spectrometry for In Vitro ADME Screening -- chapter 5 Chapter Metabolite Identi cation Strategies and Procedures -- chapter 6 Chapter Reactive Metabolite Screening and Covalent-Binding Assays -- chapter 7 Chapter Fast Metabolite Screening in a Discovery Setting -- chapter 8 Chapter Fast Chromatography with UPLC and Other Techniques -- chapter 9 Chapter Supercritical Fluid Chromatography–Mass Spectrometry -- chapter 10 Chapter Biomarkers of Ef cacy and Toxicity: Discovery and Assay -- chapter 11 Chapter Imaging Mass Spectrometry for Small Molecules -- chapter 12 Chapter MALDI IMS for Proteins and Biomarkers -- chapter 13 Chapter Ambient Ionization Methods and Their Early Applications in ADME Studies -- chapter 14 Chapter Pharmaceutical Applications of Accelerator Mass Spectrometry.