Pathology of brain aging / Janna H. Neltner and Peter T. Nelson -- Protein aggregation and neurodegeneration : tauopathies and synucleinopathies / Michel Goedert -- Prion degeneration / James A. Mastrianni -- Excitotoxicity / Mark P. Mattson -- Aetiology and pathogenesis of Parkinson disease / Ruth-Mary deSouza and Anthony H.V. Schapira -- Parkinson's disease: treatment options? surgical therapy / Travis S. Tierney and Andres M. Lozano -- Multiple system atrophy (MSA): clinical, genetics and neuropathology / Lucia V. Schottlaender [and 5 others] -- Progressive supranuclear palsy / Huw R. Morris -- Dementia with lewy bodies / Rodolfo Savica and David S. Knopman -- Corticobasal degeneration / Keith A. Josephs -- Alzheimer's disease / Qurat ul Ain Khan and Neill R. Graff-Radford -- Frontotemporal dementia / Christian Wider, Barbara Jasinska-Myga and Zbigniew K. Wszolek -- Prion diseases and other rapidly progressive dementias / Eric Eggenberger and Daniel L. Murman -- ALS and PLS / Kevin B. Boylan, Mark A. Ross and Eric J. Sorenson -- Hereditary spastic paraplegia / Pawel P. Liberski and Craig Blackstone -- Spinal muscular atrophy / Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles and Charlotte J. Sumner -- Spinal and bulbar muscular atrophy (Kennedy disease) / Erich Peter Bosch -- Optic neuropathies / Desmond Kidd -- Peripheral nerve neuropathies including CMT disease / Amelie Pandraud and Henry Houlden -- Axonal loss and neurodegeneration in multiple sclerosis / Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda and Bruce D. Trapp -- Neurodegeneration : Huntington's disease and other choreas / Salman Haider, Edward Wild and Sarah J. Tabrizi -- Spinocerebellar ataxias / H. Brent Clark and Harry T. Orr -- Ataxia telangiectasia / Malcolm Taylor -- Niemann-Pick disease / Marc C. Patterson -- X-linked adrenoleukodystrophy / Deborah L. Renaud -- Neurodegeneration with brain iron accumulation, Wilson disease, manganism / Alisdair McNeill.